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一个控制超强电离辐射抗性开关基因的研究进展

陆慧智 华跃进

陆慧智, 华跃进. 一个控制超强电离辐射抗性开关基因的研究进展[J]. 空间科学学报, 2021, 41(1): 133-140. doi: 10.11728/cjss2021.01.133
引用本文: 陆慧智, 华跃进. 一个控制超强电离辐射抗性开关基因的研究进展[J]. 空间科学学报, 2021, 41(1): 133-140. doi: 10.11728/cjss2021.01.133
LU Huizhi, HUA Yuejin. Research Progress of a Switch Gene in Response to Extreme Ionizing Radiation[J]. Journal of Space Science, 2021, 41(1): 133-140. doi: 10.11728/cjss2021.01.133
Citation: LU Huizhi, HUA Yuejin. Research Progress of a Switch Gene in Response to Extreme Ionizing Radiation[J]. Journal of Space Science, 2021, 41(1): 133-140. doi: 10.11728/cjss2021.01.133

一个控制超强电离辐射抗性开关基因的研究进展

doi: 10.11728/cjss2021.01.133
基金项目: 

国家重点研发计划项目(2017YFA0503900)和国家自然科学基金项目(31670065,31870051)共同资助

详细信息
    作者简介:

    华跃进,E-mail:yjhua@zju.edu.cn

  • 中图分类号: Q691

Research Progress of a Switch Gene in Response to Extreme Ionizing Radiation

  • 摘要: 电离辐射广泛存在于地球和空间,会引起生物体内的DNA损伤,导致机体突变甚至死亡.生物体的DNA损伤响应对于稳定基因组的完整性至关重要.耐辐射奇球菌因其超强的DNA修复能力成为研究DNA损伤修复的模式生物之一.PprI-DdrO系统是近年来发现的一种新型且高效的损伤响应途径,PprI作为响应损伤的重要开关蛋白,通过酶切DdrO调控DNA损伤响应基因的表达.本文从功能、结构、激活机制和潜在应用价值几方面描述了PprI的研究进展.

     

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  • 收稿日期:  2020-11-06
  • 刊出日期:  2021-01-15

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