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Wnt3a/β-catenin信号通路调节模拟微重力诱导的骨髓间充质干 细胞增殖抑制

杨先炯 毛新建 罗庆 宋关斌

杨先炯, 毛新建, 罗庆, 宋关斌. Wnt3a/β-catenin信号通路调节模拟微重力诱导的骨髓间充质干 细胞增殖抑制[J]. 空间科学学报, 2016, 36(1): 63-69. doi: 10.11728/cjss2016.01.063
引用本文: 杨先炯, 毛新建, 罗庆, 宋关斌. Wnt3a/β-catenin信号通路调节模拟微重力诱导的骨髓间充质干 细胞增殖抑制[J]. 空间科学学报, 2016, 36(1): 63-69. doi: 10.11728/cjss2016.01.063
YANG Xianjiong, MAO Xinjian, LUO Qing, SONG Guanbin. Wnt3a/β-catenin Signaling Pathway Mediates Inhibition of Proliferation of Mesenchymal Stem Cells Induced by Modeled Microgravity[J]. Journal of Space Science, 2016, 36(1): 63-69. doi: 10.11728/cjss2016.01.063
Citation: YANG Xianjiong, MAO Xinjian, LUO Qing, SONG Guanbin. Wnt3a/β-catenin Signaling Pathway Mediates Inhibition of Proliferation of Mesenchymal Stem Cells Induced by Modeled Microgravity[J]. Journal of Space Science, 2016, 36(1): 63-69. doi: 10.11728/cjss2016.01.063

Wnt3a/β-catenin信号通路调节模拟微重力诱导的骨髓间充质干 细胞增殖抑制

doi: 10.11728/cjss2016.01.063
基金项目: 国家自然科学基金重点项目(11032012), 中国科学 院微重力重点实验室开放课题(NML1516KFKT4-4)和重庆大学大型仪器设备开 放基金(201406150056-57)共同资助
详细信息
    通讯作者:

    宋关斌,E-mail:song@cqu.edu.cn

  • 中图分类号: Q693;V527

Wnt3a/β-catenin Signaling Pathway Mediates Inhibition of Proliferation of Mesenchymal Stem Cells Induced by Modeled Microgravity

  • 摘要: 微重力环境对骨髓间充质干细胞(MSCs)的增殖行为起着重要调节作用, 但其 中的分子机理尚不清楚. 采用平行平板旋转培养装置模拟微重力效应, 考察了 模拟微重力效应下MSCs增殖行为的变化以及Wnt3a/β-catenin信号通路在 该过程中的作用. 结果发现, 模拟微重力效应明显抑制MSCs的增殖行为, 下调 Wnt3a mRNA的表达, 降低细胞质中游离β-catenin, 减少β-catenin 向细胞核转移, 抑制Cyclin D1的表达. 结果表明, Wnt3a/β-catenin信 号通路可能介导了微重力效应诱导的MSCs增殖抑制.

     

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出版历程
  • 收稿日期:  2015-01-23
  • 修回日期:  2015-07-02
  • 刊出日期:  2016-01-15

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