180天长期密闭环境对志愿者骨代谢、糖脂代谢的影响及其相关性分析

杨超; 徐子涵; 李铠; 张洪玉; 王海龙; 吴峰; 许梓; 戴钟铨; 李莹辉

doi:10.11728/cjss2021.02.293

180天长期密闭环境对志愿者骨代谢、糖脂代谢的影响及其相关性分析

doi: 10.11728/cjss2021.02.293 cstr: 32142.14.cjss2021.02.293

杨超¹,
徐子涵^1,2,
李铠¹,
张洪玉¹,
王海龙¹,
吴峰¹,
许梓³,
戴钟铨^1,3,
李莹辉^1,2,3

1. 中国航天员科研训练中心航天医学基础与应用国家重点实验室北京 100094;
2. 哈尔滨工业大学生命科学与技术学院哈尔滨 150001;
3. 深圳市太空科技南方研究院深圳 518116

基金项目:

国家自然科学基金项目（81801872，31470832，31570858），中国航天员科研训练中心航天医学基础与应用国家重点实验室自主科研项目（SMFA17A02，SMFA17B04，SMFA17B06，SYFD1500604），青年人才托举工程项目（2015-2017，2015QNRC001），国家重大科学仪器设备开发专项（2013YQ190467）和深圳市科技计划项目（CKFW2016082915204709，CKFW2016082915204709）共同资助

详细信息

作者简介:

李莹辉,E-mail:yinghuidd@vip.sina.com;戴钟铨,E-mail:daizhq77@163.com

中图分类号: V524
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出版历程
- 收稿日期: 2018-03-14
- 修回日期: 2019-08-22
- 刊出日期: 2021-03-15

Effects of 180-day's Isolation on Bone, Glycolipid Metabolism and Their Correlation Analysis

1 State Key Laboratory of Space Medicine Fundamentals and Application, Astronaut Center of China, Beijing 100094;
2 School of Life Science and Technology, Harbin Institute of Technology, Harbin 150001;
3 Space Institute of Southern China, Shenzhen 518116

摘要

摘要: 长期空间飞行过程中航天员处于狭小密闭的失重环境中，密闭环境对机体骨代谢与糖脂代谢的影响尚不明确.通过4人180天受控生态生保系统集成实验，分析长期处于密闭环境的4名志愿者血清中骨代谢、糖脂代谢指标变化，并根据骨与能量代谢相互调控理论，分析二者相关性.实验结果表明，长期密闭舱内生活影响了骨代谢与糖脂代谢，表现为骨形成指标（BGP，PICP，BAP）的下降趋势.入舱前中后期Insulin的变化幅度较大.脂代谢类指标也有下降趋势.相关性分析表明BGP与FRUC呈极显著的正相关（r=0.525，p=0.001）；BGP与CHOL和LDL也呈显著正相关（r=0.376，p=0.024；r=0.391，p=0.018）.长期密闭环境影响机体的骨代谢与糖脂代谢，且二者存在一定关联.
- 密闭空间 /
- 骨代谢 /
- 糖脂代谢
Abstract: During the long-term space flight, the astronauts are in the confined weightlessness environment. However, the impact of confined environment on bone metabolism and glucose and lipid metabolism is not elucidated. In this paper, the changes of bone metabolism, glucose and lipid metabolism and their correlations through Space 180 CELSS System test of four volunteers were analyzed. Results showed that confined environment affected bone formation indices (BGP, PICP, BAP). Serum insulin level changed significantly during the test, and Lipid metabolism indicators have a downward trend. Correlation analysis showed that BGP was positively correlated with FRUC (r=0.525, p=0.001). There was also a significant positive correlation between BGP, CHOL and LDL (r=0.376, p=0.024; r=0.391, p=0.018). The results showed that the metabolism of bone and glycolipid was changed obviously in this experiment, and there was mutual regulation between them.
- Hermetic space /
- Bone metabolism /
- Glycolipid metabolism

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参考文献(26)

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