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180天长期密闭环境对志愿者骨代谢、糖脂代谢的影响及其相关性分析

杨超 徐子涵 李铠 张洪玉 王海龙 吴峰 许梓 戴钟铨 李莹辉

杨超, 徐子涵, 李铠, 张洪玉, 王海龙, 吴峰, 许梓, 戴钟铨, 李莹辉. 180天长期密闭环境对志愿者骨代谢、糖脂代谢的影响及其相关性分析[J]. 空间科学学报, 2021, 41(2): 293-300. doi: 10.11728/cjss2021.02.293
引用本文: 杨超, 徐子涵, 李铠, 张洪玉, 王海龙, 吴峰, 许梓, 戴钟铨, 李莹辉. 180天长期密闭环境对志愿者骨代谢、糖脂代谢的影响及其相关性分析[J]. 空间科学学报, 2021, 41(2): 293-300. doi: 10.11728/cjss2021.02.293
YANG Chao, XU Zihan, LI Kai, ZHANG Hongyu, WANG Hailong, WU Feng, XU Zi, DAI Zhongquan, LI Yinghui. Effects of 180-day's Isolation on Bone, Glycolipid Metabolism and Their Correlation Analysis[J]. Journal of Space Science, 2021, 41(2): 293-300. doi: 10.11728/cjss2021.02.293
Citation: YANG Chao, XU Zihan, LI Kai, ZHANG Hongyu, WANG Hailong, WU Feng, XU Zi, DAI Zhongquan, LI Yinghui. Effects of 180-day's Isolation on Bone, Glycolipid Metabolism and Their Correlation Analysis[J]. Journal of Space Science, 2021, 41(2): 293-300. doi: 10.11728/cjss2021.02.293

180天长期密闭环境对志愿者骨代谢、糖脂代谢的影响及其相关性分析

doi: 10.11728/cjss2021.02.293
基金项目: 

国家自然科学基金项目(81801872,31470832,31570858),中国航天员科研训练中心航天医学基础与应用国家重点实验室自主科研项目(SMFA17A02,SMFA17B04,SMFA17B06,SYFD1500604),青年人才托举工程项目(2015-2017,2015QNRC001),国家重大科学仪器设备开发专项(2013YQ190467)和深圳市科技计划项目(CKFW2016082915204709,CKFW2016082915204709)共同资助

详细信息
    作者简介:

    李莹辉,E-mail:yinghuidd@vip.sina.com;戴钟铨,E-mail:daizhq77@163.com

  • 中图分类号: V524

Effects of 180-day's Isolation on Bone, Glycolipid Metabolism and Their Correlation Analysis

  • 摘要: 长期空间飞行过程中航天员处于狭小密闭的失重环境中,密闭环境对机体骨代谢与糖脂代谢的影响尚不明确.通过4人180天受控生态生保系统集成实验,分析长期处于密闭环境的4名志愿者血清中骨代谢、糖脂代谢指标变化,并根据骨与能量代谢相互调控理论,分析二者相关性.实验结果表明,长期密闭舱内生活影响了骨代谢与糖脂代谢,表现为骨形成指标(BGP,PICP,BAP)的下降趋势.入舱前中后期Insulin的变化幅度较大.脂代谢类指标也有下降趋势.相关性分析表明BGP与FRUC呈极显著的正相关(r=0.525,p=0.001);BGP与CHOL和LDL也呈显著正相关(r=0.376,p=0.024;r=0.391,p=0.018).长期密闭环境影响机体的骨代谢与糖脂代谢,且二者存在一定关联.

     

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出版历程
  • 收稿日期:  2018-03-14
  • 修回日期:  2019-08-22
  • 刊出日期:  2021-03-15

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