EFFECT OF -6°HEAD-REST ON THE T LYMPHOCYTE AND ENDOCRINE SYSTEM

This paper is to investigate the effects of the simulated weightlessness in a minus 6°head-down bed-rest condition(SW) on the T lymphocyte proliferation stimulated with PHA and on the T lymphocyte subsets.The changes of growth factor(GH), adrenocoticotrophic hormone(ACTH),cotisol(CT)are also observed.The results show that the T lymphocyte proliferation decreased significantly (P<0.05) two days after SW,and recover to normal six days after SW. The CD3, CD4, and CD8 positive T lymphocyte appeared no obvious depression after SW.The GH concentration in plasma increased significandy(P<0.01) two days after SW,and recover tO normal six days after SW.The ACTH concentration in plasma tend to increase tWo days after SW,it seem to decrease six days after SW.The CT concentration in plasma increase significantly(P<0.05) and recover to normal six days after SW.The conclusion is that the dysfunction of T lymphocyte may be caused by the perturbations of endocrine system.