Volume 42 Issue 5
Oct.  2022
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Article Navigation >  Chinese Journal of Space Science  > 2022  >  42(5): 941-951
WANG Zhihan, RUAN Yao, ZHANG Qingye, ZHANG Hongyu. Metabolic Network Flux Balance Analysis of the Microgravity Influence on the Growth of Arabidopsis Thaliana (in Chinese). Chinese Journal of Space Science, 2022, 42(5): 941-951 doi: 10.11728/cjss2022.05.210714077
Citation: WANG Zhihan, RUAN Yao, ZHANG Qingye, ZHANG Hongyu. Metabolic Network Flux Balance Analysis of the Microgravity Influence on the Growth of Arabidopsis Thaliana (in Chinese). Chinese Journal of Space Science, 2022, 42(5): 941-951 doi: 10.11728/cjss2022.05.210714077
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Metabolic Network Flux Balance Analysis of the Microgravity Influence on the Growth of Arabidopsis Thaliana

doi: 10.11728/cjss2022.05.210714077 cstr: 32142.14.cjss2022.05.210714077

  • School of Informatics, Huazhong Agricultural University, Wuhan 430070

  • Received Date: 2021-07-14
  • Accepted Date: 2022-04-12
  • Rev Recd Date: 2022-05-25
    • Available Online: 2022-09-17
    Abstract
  • As a typical space environmental factor, the influence mechanism of microgravity on plants is a research hotspot in space life science. The microgravity environment directly or indirectly affects plant metabolism and induces many physiological adaptations. With the development of systems biology, the metabolic network model enables the modeling of plant metabolism in microgravity. In this study, the flux balance analysis method was used to study the metabolic networks of different tissues of the model plant Arabidopsis thaliana, and to explore the mechanism of the effect of microgravity on the growth and development of Arabidopsis thaliana. By comparing the biomass yield of Arabidopsis thaliana under space and ground conditions, it was found that the biomass of etiolated seedlings, seedlings, shoots, roots, and hypocotyls is decreased by 33.00%, 51.52%, 6.89%, 12.53%, and 11.70%, respectively, consistent with the growth trend of Arabidopsis thaliana in the space environment. Enrichment analysis of metabolic pathways showed that microgravity down-regulated Arabidopsis thaliana’s carbon fixation pathway, while up-regulated the pentose phosphate pathway. This result preliminarily analyzed the mechanism of microgravity influence on the growth and development of Arabidopsis thaliana and demonstrated the potential of the flux balance analysis method in the study of the biological effects of microgravity.

     

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