Volume 45 Issue 2
Apr.  2025
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Article Navigation >  Chinese Journal of Space Science  > 2025  >  45(2): 506-516 Open Access
HE Minmin, ZHU Yufeng, LÜ Xuan, TANG Guangyan, QUAN Yuan. Mechanism of the Effect of Ionizing Radiation on Human B Cells Based on Network-guided Random Forest (in Chinese). Chinese Journal of Space Science, 2025, 45(2): 506-516 doi: 10.11728/cjss2025.02.2024-0055
Citation: HE Minmin, ZHU Yufeng, LÜ Xuan, TANG Guangyan, QUAN Yuan. Mechanism of the Effect of Ionizing Radiation on Human B Cells Based on Network-guided Random Forest (in Chinese). Chinese Journal of Space Science, 2025, 45(2): 506-516 doi: 10.11728/cjss2025.02.2024-0055
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Mechanism of the Effect of Ionizing Radiation on Human B Cells Based on Network-guided Random Forest

doi: 10.11728/cjss2025.02.2024-0055 cstr: 32142.14.cjss.2024-0055

  • College of Information, Huazhong Agricultural University, Wuhan 430070

  • Received Date: 2024-04-08
  • Rev Recd Date: 2024-09-14
    • Available Online: 2024-11-02
    Abstract
  • With the intensification of the problems of the Earth’s population, energy and ecological environment, space immigration may become a feasible solution. In the space environment, ionizing radiation will damage the DNA and other molecular structures of human cells, causing cell mutation or death, increasing the risk of cancer and other diseases. The mechanism of the effect of ionizing radiation on human cells has become an urgent problem in the field of space medicine. In recent years, a large amount of spatial omics data has accumulated, and the development of bioinformatics technology provides a feasible way to solve the above problems. In this study, the Network Guided Random Forest (NGF) algorithm was used to investigate the response mechanism of human B cells to ionizing radiation. Based on gene function enrichment analysis, it was found that human B cells could not repair the damaged DNA normally after high dose of ionizing radiation, and a large number of cells suffered apoptosis or cancer. In addition, screening of potential anti-ionizing radiation drugs based on the cMap (Connectivity Map) database showed that natural products such as paclitaxel and zonicin may assist the human body in resisting ionizing radiation damage. This paper will lay a foundation for the analysis of the influence mechanism of space environment on human beings, and help astronauts to study the strategies of resisting space adversity.

     

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