Volume 43 Issue 2
Mar.  2023
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Article Navigation >  Chinese Journal of Space Science  > 2023  >  43(2): 310-320 Open Access
SUI Xiukun, GUO Zhifeng, ZHANG Hongyu, WANG Hailong, WU Feng, YANG Chao, GUO Yaxiu, MA Ting, LI Yinghui, DAI Zhongquan. Effect of Prolonged Fasting on Uric Acid Metabolism and Its Regulation Mechanism (in Chinese). Chinese Journal of Space Science, 2023, 43(2): 310-320 doi: 10.11728/cjss2023.02.220225021
Citation: SUI Xiukun, GUO Zhifeng, ZHANG Hongyu, WANG Hailong, WU Feng, YANG Chao, GUO Yaxiu, MA Ting, LI Yinghui, DAI Zhongquan. Effect of Prolonged Fasting on Uric Acid Metabolism and Its Regulation Mechanism (in Chinese). Chinese Journal of Space Science, 2023, 43(2): 310-320 doi: 10.11728/cjss2023.02.220225021
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Effect of Prolonged Fasting on Uric Acid Metabolism and Its Regulation Mechanism

doi: 10.11728/cjss2023.02.220225021 cstr: 32142.14.cjss2023.02.220225021
  • 1.

    Department of Electronic and Information Engineering, Harbin Institute of Technology, Shenzhen 518055

  • 2.

    State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing 100094

  • 3.

    Space Science and Technology Institute (Shenzhen), Shenzhen 518003

  • Received Date: 2022-02-25
  • Accepted Date: 2022-06-21
  • Rev Recd Date: 2022-10-21
    • Available Online: 2023-02-15
    Abstract
  • To investigate the changes of uric acid metabolism in rats during prolonged fasting and its potential regulatory mechanism. Sprague-Dawley (SD) rats were used as animal models. The changes of uric acid level and metabolism-related gene and protein expression in rats during different fasting periods (1, 2, 3, 5, and 7 days) were analyzed by pathological tissue sections, biochemical tests, quantitative PCR (qRT-PCR), and western blotting. The results showed that prolonged fasting did not cause significant damage to kidney tissue, but remarkedly increased the blood uric acid level and blood uricase activity. It also resulted in fluctuating changes in urine uric acid level. The mRNA and protein expression levels of main uric acid transporters were increased gradually with the fasting duration. The elevation of serum uric acid caused by prolonged fasting is related to uric acid transporter and uricase activity.

     

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